hrp0092p3-258 | Thyroid | ESPE2019

The Challenge to Treat Neonatal Autoimmune Hyperthyroidism in a Small Preterm

Lignitz Sarah , Coors Detlef , Pohlenz Joachim

Background: The prevalence of hyperthyroidism in pregnancy is about 0.2%, mostly due to Graves disease. Neonatal autoimmune hyperthyroidism caused by the transplacental passage of stimulatory thyrotropin receptor antibodies (TRAB) of the IgG class is a rare disorder. It occurs in only 2% of the neonates of mothers with Graves disease, is transient and associated with high morbidity and mortality rates up to 25%. Antithyroid drugs are the treatment ...